Hemodynamics and blood flow distribution following prolonged circulation at 5°C

ZARINS, CHRISTOPHER K,, AND DAVID B, SKINNER. Hemodynamics and blood flow distributiun following prolonged circulation at 5°C. Am. J. Physiol. 229(Z) : 275-278. 1975 .-Circulation was maintained in profoundly hypothermic dogs for 8 h at temperatures below 10°C. During cooling to 5°C cardiac output and blood pressure decreased and peripheral resistance rose. Thereafter, circuIatory dynamics remained relatively stable over the next 6 h with a gradual decline in blood pressure. The proportion of blood flow to the heart and brain increased with cooling and remained elevated throughout the hypothermia period. Despite continued circulation, pulmonary edema developed after 5-7 h and the dogs were nonviable when rewarmed.